Journal: Cell reports

Article Title: TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4 + T Cells to T reg

doi: 10.1016/j.celrep.2020.01.040

Figure Lengend Snippet: (A and B) Tlr2 , Tlr4 , Tlr7 , and Tlr9 mRNA normalized to Hprt1 mRNA in (A) whole spleen and (B) sorted DC and T cell populations in C57BL/6 mice infected with LD or HD Lm Δ actA -Ova (n = 3 per group). (C and D) p65-GFP knockin mice challenged for 24 h with HD Lm Δ actA -Ova. (C) Frequency of p65-GFP and TLR9 expression in B cells, CD8a − DC/Mac, CD8a + DCs, plasmacytoid DCs (pDCs), CD103 + DCs, red pulp macrophages (RP Macs), and marginal zone Macs (MZ Macs) (n = 3 per group). (D) Representative ImageStream images displaying TLR9 hi APC subcellular localization of p65-GFP (green) and DAPI (red) and quantitative p65-GFP nuclear translocation (n = 3 per group). (E) C57BL/6 and Tlr9 M7Btlr mice exposed to HD Lm Δ actA -Ova for 24 h. Frequency and absolute number of IL-12 (p40) + and IFN-β + APC subsets after PMA/ionomycin stimulation (n = 4 per group). (F) C57BL/6 and Batf3 −/− mice infected with HD Lm Δ actA -Ova for 24 h. Change in FoxP3 + :FoxP3 − CD4 + T cell ratio at day 1 post-infection relative to the naive state (D FoxP3 + :FoxP3 − ) (n = 7 per group).

Article Snippet: ant-IL-12 (p40) (C17.8) PE , Tonbo Biosciences , Cat#50-7123-U100.

Techniques: Infection, Knock-In, Expressing, Translocation Assay

Journal: Cell reports

Article Title: TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4 + T Cells to T reg

doi: 10.1016/j.celrep.2020.01.040

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: ant-IL-12 (p40) (C17.8) PE , Tonbo Biosciences , Cat#50-7123-U100.

Techniques: Virus, Recombinant, Enzyme-linked Immunosorbent Assay, Staining, Gene Expression, Software, Luminex

Journal: iScience

Article Title: Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation

doi: 10.1016/j.isci.2024.109496

Figure Lengend Snippet:

Article Snippet: Anti-human IL-22; Vio® B515; Isotype Human; Clone REA466 , Miltenyi Biotec , Cat#130-108-096; RRID: AB_2652431.

Techniques: Activation Assay, Control, Isolation, Recombinant, Modification, Staining, cDNA Synthesis, Gene Expression, Software

Journal: Inflammatory Intestinal Diseases

Article Title: Mucosal Healing in Crohn's Disease: Bull's Eye or Bust? The “Relative” Con Position

doi: 10.1159/000519731

Figure Lengend Snippet: Failed clinical trials in Crohn's disease

Article Snippet: Briakinumab , Anti-IL-12/23 p40 monoclonal antibody , Primary endpoint (clinical remission) at week 6 not met.

Techniques: Clinical Proteomics, Inhibition